Effects of mutations in phage restriction sites during escape from restriction–modification

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Effects of mutations in phage restriction sites during escape from restriction-modification.

Restriction-modification systems are widespread genetic elements that protect bacteria from bacteriophage infections by recognizing and cleaving heterologous DNA at short, well-defined sequences called restriction sites. Bioinformatic evidence shows that restriction sites are significantly underrepresented in bacteriophage genomes, presumably because bacteriophages with fewer restriction sites ...

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ژورنال

عنوان ژورنال: Biology Letters

سال: 2017

ISSN: 1744-9561,1744-957X

DOI: 10.1098/rsbl.2017.0646